Redox Signaling in Doxorubicin-Induced Ferroptosis
Keywords:Alas1; Cardiomyopathy; Doxorubicin; Ferroptosis; GPx4; HO-1; Nrf2
Doxorubicin is among the most widely used anticancer drugs; however, its clinical use is associated with cardiomyopathy and heart failure. Studies show ferroptosis as a pivotal form of cell death underlying doxorubicin cardiomyopathy. Recently, multiple redox signaling pathways have been discovered to underlie doxorubicin-induced ferroptosis. This Cutting-Edge Research Highlights discusses these latest advances, focusing on pathways involving Nrf2/HO-1, GPx4, and Alas1/heme synthesis.
(First online: February 19, 2023)
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