Metformin, a “Wonder Drug”, Targets METC for Pulmonary Protection
Keywords:Acute respiratory distress syndrome; Covid-19; Metformin; Mitochondrial ROS; Tuberculosis
Metformin, a widely used antidiabetic drug, possesses other beneficial activities, including cardiovascular protection, anti-tumorigenesis, antiaging, and weight control. This Cutting-Edge Research Highlights outlines some latest basic research discoveries on metformin’s suppression of mitochondrial electron transport chain (METC) in the intervention of pulmonary inflammatory disorders, including tuberculosis and acute respiratory distress syndrome in animal models. These novel discoveries further support metformin as a pleiotropic drug for treating diverse diseases.
(First online: February 19, 2023)
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